Roman Tiger, with Stewart Elliot, finished second a half length in front of Mr. Maccool, with Jose Caraballo, in third.
Adriano raised his career record to four wins from eleven starts with earnings of $713,680.
This was the first time Desmoreaux has ridden Adriano, by trainer William Mott gave him a precise briefing on him.
"Mr. Mott has him pegged perfectly," said winning rider Kent Desormeaux. "He told me a little about him and that was exactly how I was able to ride him. He got the job done. He is a nice horse. When Wesley went by me, it looked like I was going to be second to him. He made an early move and I thought I am not ready to go yet, but I have got to keep up with him at least. His turn of foot got him a couple lengths in front of me, but Adriano had not laid his body down yet. I certainly knew there was plenty left and sure enough he got there. He was just hitting his best stride at the sixteenth pole."